Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis

Abstract

Cascade reactions (also represented as domino reactions) realize the step-economical direct construction of natural product core structures. The use of atom-economical elementary reactions in cascade processes can minimize waste production and avoid prefunctionalization of the substrates. Palladium catalysis, which promotes a variety of atom-economical elementary reactions, has long been used as a powerful approach to the direct formation of complex heterocycles. In this short review, palladium-catalyzed cascade reactions for the construction of core structures of natural products reported in the last decade­ are highlighted.

1 Introduction

2 Reactions Terminated with Heteronucleophiles

2.1 Termination with Nitrogen Nucleophiles

2.2 Termination with Oxygen Nucleophiles

3 Reactions Terminated with Carbon Functional Groups

3.1 Termination with Carbon Nucleophiles

3.2 Termination with Heck-Type Reactions

4 Conclusion

Key words

cascade reaction - domino reaction - palladium catalysis - natural product synthesis - step economy

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