Synthesis 2017; 49(07): 1419-1443
DOI: 10.1055/s-0036-1589478
review
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in Cobalt Catalyzed Carbon–Carbon and Carbon–Heteroatom Bond Formation via C–H Bond Functionalization

Muhammad Usman
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi′an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Zhi-Hui Ren
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi′an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Yao-Yu Wang
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi′an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
,
Zheng-Hui Guan*
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi′an 710127, P. R. of China   Email: guanzhh@nwu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 19 September 2016

Accepted after revision: 19 October 2016

Publication Date:
06 February 2017 (online)


Abstract

Cobalt catalysts have evolved to be seen as versatile eco-compatible and economical catalysts in organic synthesis in recent years. Cobalt-catalyzed reactions are undoubtedly a classic in synthetic chemistry for the formation of carbon–carbon and carbon–heteroatom bonds. Another important aspect in this field is catalyst variants, such as low-valent and high-valent cobalt catalysts. This review summarizes the recent progress and synthetic utility of low-valent and high-valent cobalt catalysts towards C–H functionalization processes achieving C–C, C–O, C–N and C–B bond formation. Mechanistic insight is also discussed, with the goal of serving as a stepping stone for further development in this field. In addition, Csp3–H bond functionalization reactions provide many opportunities for novel synthesis approaches.
1 Introduction
2 Carbon–Carbon Bond Formation

2.1 Csp2–Csp3 Bond Formation

2.2 Csp2–Csp2 Bond Formation

3 Carbon–Nitrogen Bond Formation

4 Csp3–H Bond Functionalization

5 Carbon–Oxygen Bond Formation

6 Carbon–Boron Bond Formation

7 Conclusion