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Synthesis 2017; 49(10): 2101-2116
DOI: 10.1055/s-0036-1589484
DOI: 10.1055/s-0036-1589484
review
Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains
Further Information
Publication History
Received: 19 December 2016
Accepted after revision: 18 January 2017
Publication Date:
24 March 2017 (online)
Abstract
This review reports the synthesis of propargylic derivatives with alkyl chains bearing either one fluorine or a gem-difluoro system. The preparation of the different categories of fluorinated derivatives is analyzed in a systematic manner, based on the nature of substituents close to the fluorine atom(s). In the second part of this review are summarized the synthetic applications of these fluorinated propargylic intermediates, focusing mainly on the preparation of carbo- and heterocyclic derivatives.
1 Introduction
2 Synthesis of Propargylic Fluorides
3 Use of Propargylic Fluorides in the Preparation of Carbo- and Heterocycles with Fluorine-Containing Side Chains
4 Conclusions and Perspectives
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See, for instance:
For selected reviews on this topic, see:
For reviews on propargylic fluorides, see:
For recent discussions on the design and use of chemical libraries in medicinal chemistry and drug discovery, see: