A palladium-catalyzed conjugate addition of arylboronic acids to α-substituted cyclic
enones was developed to give α,β-disubstituted ketones with high diastereoselectivity.
Mechanistic investigation showed that the high diastereoselectivity was realized through
epimerization.
Key words
palladium - conjugate addition - boronic acid - cyclic enone - diastereoselectivity