Synthesis, Table of Contents Synthesis 2017; 49(22): 4986-4995DOI: 10.1055/s-0036-1590823 paper © Georg Thieme Verlag Stuttgart · New York Organocatalytic Asymmetric Synthesis of 2,3′-Connected Bis-Indolinones by Mannich Reactions of N-Acetylindolin-3-ones with Isatin N-Boc Ketimines V. Pratap Reddy Gajulapalli a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany , Ehsan Jafari a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany , Dipti S. Kundu a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany , Suruchi Mahajan a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany , Anssi Peuronen b Department of Chemistry, Nanoscience Center, University of Jyvaskyla, 40014 JYU, Finland Email: enders@rwth-aachen.de , Kari Rissanen b Department of Chemistry, Nanoscience Center, University of Jyvaskyla, 40014 JYU, Finland Email: enders@rwth-aachen.de , Dieter Enders* a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Abstract A highly diastereo- and enantioselective Mannich reaction of N-acetylindolin-3-ones with isatin N-Boc ketimines to form 2,3′-connected bis-indolinones is developed employing a low loading of a readily available bifunctional thiourea catalyst. 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