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Synthesis 2017; 49(22): 4917-4930
DOI: 10.1055/s-0036-1590881
DOI: 10.1055/s-0036-1590881
short review
Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications
XGH thanks the Natural Science Foundation of China (21502076), Natural Science Foundation of Jiangxi Province (20161BAB213068) and Outstanding Young Talents Scheme of Jiangxi Province (2017) for support.Further Information
Publication History
Received: 13 June 2017
Accepted after revision: 18 July 2017
Publication Date:
28 August 2017 (online)
![](https://www.thieme-connect.de/media/synthesis/201722/lookinside/thumbnails/ss-2017-m0392-sr_10-1055_s-0036-1590881-1.jpg)
Abstract
This short review describes the development of new reagents and methods for the deoxyfluorination of phenols and alcohols during the period of 2011 to 2017. Important advances in the mechanistic understanding of these processes are discussed. The continuing importance of deoxyfluorination chemistry for the synthesis of valuable target molecules is highlighted through case studies including examples of 18F-radiosynthesis and the preparation of exotic multifluorinated compounds.
1 Introduction
2 New Deoxyfluorination Reagents
3 Novel Applications of ‘Legacy’ Deoxyfluorinating Reagents
4 Conclusions and Future Directions
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