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Synthesis 2018; 50(03): 440-469
DOI: 10.1055/s-0036-1590958
DOI: 10.1055/s-0036-1590958
review
Recent Advances in the Catalytic Asymmetric Construction of Phosphorus-Substituted Quaternary Carbon Stereocenters
We are grateful for the financial support from Chengdu University New Faculty Start-up Funding (No. 2081916045) and the Open Project Program of Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province (No. ARRLKF16-03).Weitere Informationen
Publikationsverlauf
Received: 19. August 2017
Accepted after revision: 19. Oktober 2017
Publikationsdatum:
27. November 2017 (online)
Abstract
Phosphorus-substituted quaternary carbon stereocenters exist widely in drugs and biologically active compounds. Catalytic asymmetric synthesis of such quaternary carbon stereogenic centers is of significant importance, with four synthetic strategies being established. This review summarizes the recent progress in this field, including the advantages and limitations of each strategy, briefly discusses the reaction mechanisms and challenges, and outlines synthetic opportunities still open.
1 Introduction
2 Asymmetric Hydrophosphonylation
3 Asymmetric Electrophilic Phosphination
4 Asymmetric Functionalization of P-Substituted Methine Compounds
5 Asymmetric Addition to α-Keto- or α-Ketiminophosphonates
6 Conclusion
-
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For reviews:
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