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CC BY-ND-NC 4.0 · SynOpen 2017; 01(01): 0125-0128
DOI: 10.1055/s-0036-1591507
DOI: 10.1055/s-0036-1591507
paper
An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues
Further Information
Publication History
Received: 18 August 2017
Accepted after revision: 04 October 2017
Publication Date:
20 October 2017 (online)
Abstract
The synthesis of Calebin-A (10a) and analogues (10b–d), which are minor but pharmacologically active components (<0.01% of the oleoresin) of curcuma longa, is described. This flexible synthesis is achieved under near neutral conditions in water/solvent biphasic medium at room temperature without involving any protecting groups.
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