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Synthesis 2018; 50(09): 1883-1890
DOI: 10.1055/s-0036-1591543
DOI: 10.1055/s-0036-1591543
paper
Synthesis of Cyclic 3-Aryl-Substituted 1,2-Dicarbonyl Compounds via Suzuki Cross-Coupling Reactions
This work has been supported by the Estonian Ministry of Education and Research grants IUT 19-32 and IUT23-7 and the Centre of Excellence in Molecular Cell Engineering (No. 2014-2020.4.01.15-0013).Further Information
Publication History
Received: 17 December 2017
Accepted after revision: 19 January 2018
Publication Date:
12 February 2018 (online)
Abstract
A method for the synthesis of cyclic 3-aryl- and heteroaryl-substituted 1,2-dicarbonyl compounds with different ring sizes by using a Suzuki cross-coupling reaction between 3-halo-1,2-dicarbonyl compounds and arylboronic acids is developed. The 3-halo-1,2-dicarbonyl substrates are easily available from 1,2-dicarbonyl compounds. The method is versatile, affording good to high yields of the target compounds.
Key words
Suzuki cross-coupling - dicarbonyl compounds - halodiketones - arylation - palladium catalysisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591543.
- Supporting Information
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