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Synthesis 2018; 50(11): 2247-2254
DOI: 10.1055/s-0036-1591569
DOI: 10.1055/s-0036-1591569
paper
Copper-Catalyzed S-Arylation of Arylthioureas by Using Diaryliodonium Salts
We are thankful for support from the National Natural Science Foundation of China (21302150, 11405050), Foundation of Chen-Guang Program from Hubei Association for Science and Technology, Foundation of Chutian Distinguished Fellow from Hubei Provincial Department of Education, and Foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology.Further Information
Publication History
Received: 15 February 2018
Accepted after revision: 19 March 2018
Publication Date:
25 April 2018 (online)
Abstract
A convenient and efficient copper-catalyzed S-arylation of arylthioureas using diaryliodonium salts is reported. The desired arylisothioureas were synthesized in good yields in the presence of CuCl as catalyst and K2CO3 as base, and a wide variety of functional groups on the arylthioureas and diaryliodonium salts were tolerated. The protocol affords an alternative synthesis of some potentially useful biological and pharmaceutical compounds.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591569.
- Supporting Information
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