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Synlett 2018; 29(13): 1717-1722
DOI: 10.1055/s-0036-1591578
letter
© Georg Thieme Verlag Stuttgart · New York

An Efficient One-Pot Multicomponent Synthesis of Tetracyclic Quinazolino[4,3-b]quinazolines by Sequential C–N Bond Formation and Copper-Mediated Aerobic Oxidative Cyclization

Gal Reddy Potuganti
a   Division of Crop Protection Chemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India
,
Divakar Reddy Indukuri
a   Division of Crop Protection Chemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India
,
Manjula Alla*
a   Division of Crop Protection Chemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India
b   AcSIR–Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India   Email: manjula@iict.res.in
› Author Affiliations
Further Information

Publication History

Received: 06 February 2018

Accepted after revision: 05 April 2018

Publication Date:
04 May 2018 (online)

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Abstract

An efficient one-pot synthesis of quinazolino[4,3-b]quinazoline derivatives has been accomplished, starting from 2-(2-bromo­phenyl)quinazolin-4(3H)-one, aldehydes, and various nitrogen sources under aerobic conditions. The multicomponent protocol is mediated by copper(I) salts and involves amination of 2-(2-bromophenyl)quinazolin-4(3H)-one, followed by condensation with the aldehyde and an oxidative cyclization to give the target compounds in moderate to good yields.

Key words

quinazolinoquinazoline - copper catalysis - oxidative cyclization - C–N bond formation.

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591578.
  • Supporting Information
 

  • References

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