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Synthesis 2018; 50(16): 3243-3249
DOI: 10.1055/s-0036-1591589
DOI: 10.1055/s-0036-1591589
paper
Synthesis of Indolo[2,1-a]isoquinolines via Copper-Catalyzed C–C Coupling and Cyclization of 2-(2-Bromoaryl)-1H-indoles with 1,3-Diketones
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2017R1D1A1B03028226). P.D.Q.D. thanks Y. M. Park, Internal Medicine of Geoje Medical Center (Gyeongnam, Republic of Korea) for partial financial support during his stay in the Republic of Korea.Further Information
Publication History
Received: 23 March 2018
Accepted after revision: 23 April 2018
Publication Date:
12 June 2018 (online)
Abstract
2-(2-Bromoaryl)-1H-indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1-a]isoquinolines in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591589.
- Supporting Information
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