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CC BY-ND-NC 4.0 · SynOpen 2018; 02(01): 0017-0024
DOI: 10.1055/s-0036-1591754
DOI: 10.1055/s-0036-1591754
paper
Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
Further Information
Publication History
Received: 03 November 2017
Accepted after revision: 24 December 2017
Publication Date:
29 January 2018 (online)
Abstract
A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591754.
- Supporting Information
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