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Synthesis 2018; 50(08): 1610-1620
DOI: 10.1055/s-0036-1591773
DOI: 10.1055/s-0036-1591773
feature
Synthesis of Benzopyran-Fused Flavone Derivatives via Microwave-Assisted Intramolecular C–H Activation
The research was financially supported by the EU and co-financed by the European Development Fund under the project GINOP-2.3.2-15-2016-00008.Further Information
Publication History
Received: 16 December 2017
Accepted after revision: 12 February 2018
Publication Date:
07 March 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201808/lookinside/thumbnails/ss-2017-z0820-fa_10-1055_s-0036-1591773-1.jpg)
Dedicated to the memory of Prof. Tamás Patonay
Abstract
A microwave-assisted intramolecular direct arylation method for the synthesis of benzopyran-fused flavone derivatives containing natural flavone backbones is described. Different polyalkoxy flavones were synthesized and functionalized with 2-bromobenzyl bromide. The resulting compounds were subjected to palladium-catalyzed intramolecular direct arylation reactions supported by microwave irradiation to produce fused tetracyclic flavones. In the case of the 7-substituted chrysin derivative, the regioselectivity of the coupling was also examined.
Key words
flavones - C–H bond activation - palladium - intramolecular direct arylation - microwave chemistrySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591773.
- Supporting Information
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