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CC BY-ND-NC 4.0 · SynOpen 2018; 02(01): 0006-0016
DOI: 10.1055/s-0036-1591891
DOI: 10.1055/s-0036-1591891
paper
Thiocyanation of Pyrazoles Using KSCN/K2S2O8 Combination
We thank the Thailand Research Fund (BRG5850012 and IRN58W0005), the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Postgraduate Education Research Development Office, Office of the Higher Education Commission, Ministry of Education, Mahidol University under the National Research Universities Initiative, PICS6663 ISMA (France/Thailand), and the Franco–Thai Cooperation Program in Higher Education and Research (PHC Siam 2017) for financial support.Further Information
Publication History
Received: 17 October 2017
Accepted after revision: 16 December 2017
Publication Date:
23 January 2018 (online)
Abstract
A convenient and practical thiocyanation of pyrazoles is reported employing a combination of KSCN and K2S2O8 in dimethyl sulfoxide (DMSO). The salient features of the present reaction include environmentally benign reagents and solvents, and simple operation. The reaction shows wide functional group tolerance and gives moderate to excellent yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591891.
- Supporting Information
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Some examples of Sandmeyer type reactions to prepare thiocyanates:
For selected examples, see:
For selected examples, see: