Thiocyanation of Pyrazoles Using KSCN/K₂S₂O₈ Combination

Abstract

A convenient and practical thiocyanation of pyrazoles is reported employing a combination of KSCN and K₂S₂O₈ in dimethyl sulfoxide (DMSO). The salient features of the present reaction include environmentally benign reagents and solvents, and simple operation. The reaction shows wide functional group tolerance and gives moderate to excellent yields.

Key words

thiocyanation - pyrazoles - potassium thiocyanate - potassium persulfate - heterocycle

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