One-Step O-Demethyl-Decarboxylation of ortho-Methoxy Aromatic Carboxylic Acids

Gérard Cahiez; Alban Moyeux; Edouard Zhou; Maël Poizat

doi:10.1055/s-0036-1591912

Synthesis, Inhaltsverzeichnis

Synthesis 2018; 50(10): 2119-2123
DOI: 10.1055/s-0036-1591912

paper

One-Step O-Demethyl-Decarboxylation of ortho-Methoxy Aromatic Carboxylic Acids

Gérard Cahiez*

^aInstitut de Recherche de Chimie Paris, CNRS (UMR 8247) – Chimie ParisTech, PSL Research University, 11 rue Pierre et Marie Curie, 75005 Paris, France

,

Alban Moyeux

^aInstitut de Recherche de Chimie Paris, CNRS (UMR 8247) – Chimie ParisTech, PSL Research University, 11 rue Pierre et Marie Curie, 75005 Paris, France

^bUniversité Paris 13, Sorbonne Paris Cité, 74 rue Marcel Cachin, 93017 Bobigny, France eMail: Gerard.cahiez@chimie-paristech.fr

,

Edouard Zhou

^aInstitut de Recherche de Chimie Paris, CNRS (UMR 8247) – Chimie ParisTech, PSL Research University, 11 rue Pierre et Marie Curie, 75005 Paris, France

,

Maël Poizat

^aInstitut de Recherche de Chimie Paris, CNRS (UMR 8247) – Chimie ParisTech, PSL Research University, 11 rue Pierre et Marie Curie, 75005 Paris, France

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Abstract

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Abstract

A highly selective decarboxydemethylation of o-methoxyarenecarboxylic acids is described. The reaction takes place in DMPU at 170 °C in the presence of TMEDA and iron powder. A similar reaction has not been reported until now.

Key words

ether C–O cleavage - decarboxylation - aryl methyl ethers - phenols - iron catalysis

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Referenzen

References

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