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AJP Rep 2016; 06(04): e417-e420
DOI: 10.1055/s-0036-1597266
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Adenovirus and “Culture-Negative Sepsis” in a Preterm Neonate

Mohannad Moallem
1   Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
,
Eunkyung Song
2   Division of Pediatric Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
,
Preeti Jaggi
2   Division of Pediatric Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
,
Miriam R. Conces
3   Department of Pathology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
,
Adriana E. Kajon
4   Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico
,
Pablo J. Sánchez
1   Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
2   Division of Pediatric Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio
› Author Affiliations
Further Information

Publication History

02 August 2016

11 October 2016

Publication Date:
05 December 2016 (online)

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Abstract

Background Respiratory viral infections remain an underrecognized cause of morbidity and mortality among preterm infants in the neonatal intensive care unit (NICU).

Case Report An eight day old, 650 gram birth weight, 23 weeks' gestational age female developed “culture-negative” sepsis manifested by respiratory deterioration, hypoxia, leukocytosis, and thrombocytopenia. She was diagnosed with pneumonia and hepatitis due to adenovirus HAdV-D (H29F9) by polymerase chain reaction (PCR) testing, but died at the age of 18 days despite treatment with cidofovir and immune globulin intravenous.

Conclusion As the ability to diagnosis respiratory viral infections in the NICU has improved greatly with the use of PCR testing, the impact and contribution of these viruses to neonatal disease is now being recognized and the notion of “culture-negative” sepsis needs reassessment. The diagnosis of these infections in high risk infants is important not only for etiologic and epidemiologic reasons but ultimately for informing antimicrobial stewardship efforts.

Keywords

adenovirus - preterm infant - respiratory virus - neonatal intensive care unit
 

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