Serotype Distribution and Antimicrobial Resistance of Invasive S. pneumoniae among Indian Children before the Introduction of Pneumococcal Conjugate Vaccine

Feroze Ganaie; Vandana Govindan; Geetha Nagraj; K. L. Ravikumar

doi:10.1055/s-0036-1597650

Journal of Pediatric Infectious Diseases, Inhaltsverzeichnis

J Pediatr Infect Dis 2016; 11(04): 118-125
DOI: 10.1055/s-0036-1597650

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Serotype Distribution and Antimicrobial Resistance of Invasive S. pneumoniae among Indian Children before the Introduction of Pneumococcal Conjugate Vaccine

Autor*innen

Feroze Ganaie

¹Central Research Laboratory, Department of Microbiology, Kempegowda Institute of Medical Sciences, Hospital and Research Center, Bangalore, India
Vandana Govindan

¹Central Research Laboratory, Department of Microbiology, Kempegowda Institute of Medical Sciences, Hospital and Research Center, Bangalore, India
Geetha Nagraj

¹Central Research Laboratory, Department of Microbiology, Kempegowda Institute of Medical Sciences, Hospital and Research Center, Bangalore, India
K. L. Ravikumar

¹Central Research Laboratory, Department of Microbiology, Kempegowda Institute of Medical Sciences, Hospital and Research Center, Bangalore, India

Abstract

This study was conducted to provide current information on serotype distribution and drug resistance patterns of invasive Streptococcus pneumoniae among children. Sterile site samples from 1,504 children ≤5 years, who were clinically and radiologically suspected of having invasive pneumococcal infection were evaluated. The leading serotypes causing invasive pneumococcal disease (IPD) were 1, 6B, and 14. High-level penicillin resistance was observed in 11% of isolates belonging to serotypes 6B, 1, and 5. Multidrug resistance was observed in 24% of strains. Our results reveal that PCV-10 and PCV-13 vaccines can protect against 68% and 78% of IPD serotypes, respectively.

Keywords

invasive pneumococcal disease - serotyping - antimicrobial resistance

Volltext

Referenzen

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