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Am J Perinatol 2017; 34(08): 780-786
DOI: 10.1055/s-0037-1598245
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Lenticulostriate Vasculopathy and Neurodevelopmental Outcomes in Preterm Infants: A Systematic Review

Abby Robinson
1   Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
John Flibotte
2   Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
3   Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Summer L. Kaplan
4   Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
,
Sara B. DeMauro
2   Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
3   Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
› Author Affiliations
Further Information

Publication History

24 August 2016

05 January 2017

Publication Date:
13 February 2017 (online)

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Abstract

Objective The objective of this study was to perform a systematic review of all studies that report neurodevelopmental outcomes at 12 months' corrected age or later for preterm infants (< 32 weeks) who are diagnosed with lenticulostriate vasculopathy (LSV) on cranial ultrasound.

Study Design This is a systematic review.

Results We identified 501 unique publications of which 3 met all prespecified eligibility criteria. Neurodevelopmental outcome data were available for 44 preterm infants with LSV. There were mixed results from the studies: the first reported impairments of mental development; the second reported impairments of motor development only; and finally, the third reported that three of three preterm infants with LSV had mild or moderate developmental delay.

Conclusion The available results raise some concern for future impairments in preterm infants with LSV, but they are conflicting and inconclusive. There is insufficient evidence about the neurodevelopmental implications of LSV in preterm infants to inform counseling of parents.

Keywords

lenticulostriate vasculopathy - preterm infants - cranial ultrasound - neurodevelopmental outcomes
 

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