Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

John M. Daniel IV; Philip A. Bernard; Sean C. Skinner; Prasad Bhandary; Ana Ruzic; Matthew K. Bacon; Hubert O. Ballard

doi:10.1055/s-0037-1599150

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2018; 07(01): 007-013
DOI: 10.1055/s-0037-1599150

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

John M. Daniel IV

¹Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States

,

Philip A. Bernard

²Division of Pediatric Critical Care, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States

,

Sean C. Skinner

³Division of Pediatric Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States

,

Prasad Bhandary

¹Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States

,

Ana Ruzic

³Division of Pediatric Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States

,

Matthew K. Bacon

²Division of Pediatric Critical Care, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States

,

Hubert O. Ballard

¹Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States

› Author Affiliations

Abstract

In extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates (n = 44) who had undergone ECLS for noncardiac indications from 2009 to 2015. Between the two groups (PMP n = 21, PP n = 23), the PP oxygenators failed 91% of the time, whereas the PMP oxygenators failed 43% of the time (p < 0.05). Analysis suggests PMP oxygenators are less prone to failure than PP oxygenators, and they require fewer number of oxygenator changes during a neonatal ECLS.

Keywords

extracorporeal membrane oxygenation - neonatal - oxygenator - complications

Full Text

References

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