Lacosamide Lowers Valproate and Levetiracetam Levels

Maria Tountopoulou; Bernhard Weschke; Angela M. Kaindl

doi:10.1055/s-0037-1600112

Neuropediatrics, Table of Contents

Neuropediatrics 2017; 48(03): 188-189
DOI: 10.1055/s-0037-1600112

Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Lacosamide Lowers Valproate and Levetiracetam Levels

Maria Tountopoulou

¹Department of Pediatric Neurology, Center for Chronically Sick Children, Charité University Medicine Berlin, Berlin, Germany

,

Bernhard Weschke

¹Department of Pediatric Neurology, Center for Chronically Sick Children, Charité University Medicine Berlin, Berlin, Germany

,

Angela M. Kaindl

¹Department of Pediatric Neurology, Center for Chronically Sick Children, Charité University Medicine Berlin, Berlin, Germany

²Institute of Cell Biology and Neurobiology, Charité University Medicine Berlin, Berlin, Germany

› Author Affiliations

Abstract

Lacosamide (LCM) due to no known drug interaction and the absence of metabolic enzyme induction is a good candidate for an add-on medication, especially in combination with lamotrigine, levetiracetam (LEV), oxcarbazepine, topiramate, and valproic acid (VPA). Here we report for the first time, to our knowledge, that LCM can lower VPA and LEV serum levels. At present, there are no known explicable mechanisms of action of LCM, which lowers VPA and LEV. Here observed drug interaction of LCM is of clinical significance, which might be useful for other colleagues in the field.

Keywords

lacosamide - valproate - levetiracetam - interaction - drug-level

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References

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