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Journal of Pediatric Biochemistry 2016; 06(04): 191-198
DOI: 10.1055/s-0037-1601559
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Sleep in Children with Neuromuscular Diseases

Alessandro Onofri
1   Department of Molecular and Clinical Medicine, Faculty of Psycology, Sapienza University of Rome, Unit of Pneumology, Sant'Andrea Hospital, Rome, Italy
,
Elisabetta Verrillo
2   Respiratory Unit, University Department of Pediatrics (DPUO), Bambino Gesù Children's Hospital, Rome, Italy
,
Renato Cutrera
2   Respiratory Unit, University Department of Pediatrics (DPUO), Bambino Gesù Children's Hospital, Rome, Italy
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Publikationsverlauf

19. Februar 2017

04. März 2017

Publikationsdatum:
04. April 2017 (online)

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Abstract

Neuromuscular diseases are a heterogeneous group of diseases affecting the nerves, muscles, anterior horn cells, or the neuromuscular junctions. They cause muscular weakness and, in most cases, involve the respiratory system, with a variable course that can lead to respiratory failure. Sleep disorders are often present in these patients, and their evaluation is necessary to assess the requirements for correct management. Hypoventilation, obstructive sleep apnea, and central apneas must be assessed and eventually treated with mechanical ventilatory support. Polysomnography with capnography is the gold standard in assessing sleep-disordered breathing. This review aims to provide an overview of the literature on the most common neuromuscular diseases with related sleep breathing disorders in children, highlighting the main features of sleep in these patients and the role of noninvasive ventilation in treating these conditions.

Keywords

neuromuscular diseases - sleep-disordered breathing - polysomnography - sleep related hypoventilation - obstructive sleep apnea - noninvasive ventilation
 

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