Sleep in Children with Neuromuscular Diseases

Alessandro Onofri; Elisabetta Verrillo; Renato Cutrera

doi:10.1055/s-0037-1601559

Journal of Pediatric Biochemistry, Inhaltsverzeichnis

Journal of Pediatric Biochemistry 2016; 06(04): 191-198
DOI: 10.1055/s-0037-1601559

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Sleep in Children with Neuromuscular Diseases

Alessandro Onofri

¹Department of Molecular and Clinical Medicine, Faculty of Psycology, Sapienza University of Rome, Unit of Pneumology, Sant'Andrea Hospital, Rome, Italy

,

Elisabetta Verrillo

²Respiratory Unit, University Department of Pediatrics (DPUO), Bambino Gesù Children's Hospital, Rome, Italy

,

Renato Cutrera

²Respiratory Unit, University Department of Pediatrics (DPUO), Bambino Gesù Children's Hospital, Rome, Italy

› Institutsangaben

Abstract

Neuromuscular diseases are a heterogeneous group of diseases affecting the nerves, muscles, anterior horn cells, or the neuromuscular junctions. They cause muscular weakness and, in most cases, involve the respiratory system, with a variable course that can lead to respiratory failure. Sleep disorders are often present in these patients, and their evaluation is necessary to assess the requirements for correct management. Hypoventilation, obstructive sleep apnea, and central apneas must be assessed and eventually treated with mechanical ventilatory support. Polysomnography with capnography is the gold standard in assessing sleep-disordered breathing. This review aims to provide an overview of the literature on the most common neuromuscular diseases with related sleep breathing disorders in children, highlighting the main features of sleep in these patients and the role of noninvasive ventilation in treating these conditions.

Keywords

neuromuscular diseases - sleep-disordered breathing - polysomnography - sleep related hypoventilation - obstructive sleep apnea - noninvasive ventilation

Volltext

Referenzen

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