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Neuropediatrics 2017; 48(06): 403-412
DOI: 10.1055/s-0037-1601858
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

Dimitrios M. Anestis
1   Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece
,
Parmenion P. Tsitsopoulos
1   Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece
,
Christina A. Ble
1   Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece
,
Vassilios Tsitouras
2   Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
,
Christos A. Tsonidis
1   Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

12 September 2016

01 March 2017

Publication Date:
11 April 2017 (online)

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Abstract

Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

Keywords

glioblastoma multiforme - congenital brain tumors - antenatal diagnosis - infancy - treatment - outcome
 

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