Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

Dimitrios M. Anestis; Parmenion P. Tsitsopoulos; Christina A. Ble; Vassilios Tsitouras; Christos A. Tsonidis

doi:10.1055/s-0037-1601858

Neuropediatrics, Table of Contents

Neuropediatrics 2017; 48(06): 403-412
DOI: 10.1055/s-0037-1601858

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor

Dimitrios M. Anestis

¹Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece

,

Parmenion P. Tsitsopoulos

¹Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece

,

Christina A. Ble

¹Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece

,

Vassilios Tsitouras

²Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom

,

Christos A. Tsonidis

¹Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece

› Author Affiliations

Abstract

Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.

Keywords

glioblastoma multiforme - congenital brain tumors - antenatal diagnosis - infancy - treatment - outcome

Full Text

References

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