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DOI: 10.1055/s-0037-1602580
Using Ventilator-Associated Pneumonia Rates as a Health Care Quality Indicator: A Contentious Concept
Publication History
Publication Date:
04 June 2017 (online)
Abstract
Pneumonia is a leading cause of hospital-acquired infections, although reported rates of ventilator-associated pneumonia (VAP) have been declining in recent years. A multifaceted infection prevention approach, using a “ventilator bundle,” has been shown to reduce the frequency of VAP, while improving other patient outcomes. Because of difficulties in defining VAP, the Center for Medicare and Medicaid Service introduced a new streamlined ventilator-associated event (VAE) definition in 2013 for the surveillance of complications in mechanically ventilated patients. VAE measures are increasingly being measured by institutions in the United States in place of VAP rates and as a potential measure of the quality of intensive care unit (ICU) care. However, there is increased recognition that the streamlined definitions identify a different subset of patients than those identified by traditional VAP surveillance and that VAP prevention strategies may not impact all the causes of VAE. Also, VAP and VAE rates may not always reflect the quality of care in a given ICU, especially since patient factors, beyond the control of the hospital, may impact the rates of VAP and VAE. In this review, we discuss the issues related to VAP as a quality measure and the areas of uncertainty related to the new VAE definitions.
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References
- 1 Rello J, Ollendorf DA, Oster G. , et al; VAP Outcomes Scientific Advisory Group. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002; 122 (06) 2115-2121
- 2 Dudeck MA, Horan TC, Peterson KD. , et al. National Healthcare Safety Network (NHSN) report, data summary for 2009, device-associated module. Am J Infect Control 2011; 39 (05) 349-367
- 3 Reducing hospital-acquired conditions. Content last reviewed December 2016. Agency for Healthcare Research and Quality, Rockville, MD. 2017. Available at: http://www.ahrq.gov/professionals/quality-patient-safety/hac/index.html . Accessed February 27, 2017
- 4 Metersky ML, Wang Y, Klompas M, Eckenrode S, Bakullari A, Eldridge N. Trend in ventilator-associated pneumonia rates between 2005 and 2013. JAMA 2016; 316 (22) 2427-2429
- 5 Dick AW, Perencevich EN, Pogorzelska-Maziarz M, Zwanziger J, Larson EL, Stone PW. A decade of investment in infection prevention: a cost-effectiveness analysis. Am J Infect Control 2015; 43 (01) 4-9
- 6 Niederman MS. Hospital-acquired pneumonia, health care-associated pneumonia, ventilator-associated pneumonia, and ventilator-associated tracheobronchitis: definitions and challenges in trial design. Clin Infect Dis 2010; 51 (Suppl. 01) S12-S17
- 7 Magill SS, Klompas M, Balk R. , et al. Executive summary: Developing a new, national approach to surveillance for ventilator-associated events. Ann Am Thorac Soc 2013; 10 (06) S220-S223
- 8 Niederman MS, Nair GB. Managing ventilator complications in a “VACuum” of data. Chest 2015; 147 (01) 5-6
- 9 Safdar N, Dezfulian C, Collard HR, Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005; 33 (10) 2184-2193
- 10 Niederman MS, Craven DE. , et al; American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171 (04) 388-416
- 11 Grgurich PE, Hudcova J, Lei Y, Sarwar A, Craven DE. Diagnosis of ventilator-associated pneumonia: controversies and working toward a gold standard. Curr Opin Infect Dis 2013; 26 (02) 140-150
- 12 Klompas M, Platt R. Ventilator-associated pneumonia--the wrong quality measure for benchmarking. Ann Intern Med 2007; 147 (11) 803-805
- 13 Umscheid CA, Mitchell MD, Doshi JA, Agarwal R, Williams K, Brennan PJ. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect Control Hosp Epidemiol 2011; 32 (02) 101-114
- 14 Matar DS, Pham JC, Louis TA, Berenholtz SM. Achieving and sustaining ventilator-associated pneumonia-free time among intensive care units (ICUs): evidence from the Keystone ICU Quality Improvement Collaborative. Infect Control Hosp Epidemiol 2013; 34 (07) 740-743
- 15 Lambert ML, Silversmit G, Savey A. , et al. Preventable proportion of severe infections acquired in intensive care units: case-mix adjusted estimations from patient-based surveillance data. Infect Control Hosp Epidemiol 2014; 35 (05) 494-501
- 16 Resar R, Pronovost P, Haraden C, Simmonds T, Rainey T, Nolan T. Using a bundle approach to improve ventilator care processes and reduce ventilator-associated pneumonia. Jt Comm J Qual Patient Saf 2005; 31 (05) 243-248
- 17 Morris AC, Hay AW, Swann DG. , et al. Reducing ventilator-associated pneumonia in intensive care: impact of implementing a care bundle. Crit Care Med 2011; 39 (10) 2218-2224
- 18 Bouadma L, Deslandes E, Lolom I. , et al. Long-term impact of a multifaceted prevention program on ventilator-associated pneumonia in a medical intensive care unit. Clin Infect Dis 2010; 51 (10) 1115-1122
- 19 Brown J, Doloresco Iii F, Mylotte JM. “Never events”: not every hospital-acquired infection is preventable. Clin Infect Dis 2009; 49 (05) 743-746
- 20 Sundar KM, Nielsen D, Sperry P. Comparison of ventilator-associated pneumonia (VAP) rates between different ICUs: Implications of a zero VAP rate. J Crit Care 2012; 27 (01) 26-32
- 21 Stevens JP, Kachniarz B, Wright SB. , et al. When policy gets it right: variability in u.s. Hospitals' diagnosis of ventilator-associated pneumonia*. Crit Care Med 2014; 42 (03) 497-503
- 22 Klompas M, Kleinman K, Khan Y. , et al; CDC Prevention Epicenters Program. Rapid and reproducible surveillance for ventilator-associated pneumonia. Clin Infect Dis 2012; 54 (03) 370-377
- 23 Klompas M, Magill S, Robicsek A. , et al; CDC Prevention Epicenters Program. Objective surveillance definitions for ventilator-associated pneumonia. Crit Care Med 2012; 40 (12) 3154-3161
- 24 Klompas M. Potential strategies to prevent ventilator-associated events. Am J Respir Crit Care Med 2015; 192 (12) 1420-1430
- 25 Hayashi Y, Morisawa K, Klompas M. , et al. Toward improved surveillance: the impact of ventilator-associated complications on length of stay and antibiotic use in patients in intensive care units. Clin Infect Dis 2013; 56 (04) 471-477
- 26 Boyer AF, Schoenberg N, Babcock H, McMullen KM, Micek ST, Kollef MH. A prospective evaluation of ventilator-associated conditions and infection-related ventilator-associated conditions. Chest 2015; 147 (01) 68-81
- 27 Muscedere J, Sinuff T, Heyland DK. , et al; Canadian Critical Care Trials Group. The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated. Chest 2013; 144 (05) 1453-1460
- 28 Bouadma L, Sonneville R, Garrouste-Orgeas M. , et al; OUTCOMEREA Study Group. Ventilator- associated events: prevalence, outcome, and relationship with ventilator-associated pneumonia. Crit Care Med 2015; 43 (09) 1798-1806
- 29 Klein Klouwenberg PM, van Mourik MS, Ong DS. , et al; MARS Consortium. Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation. Am J Respir Crit Care Med 2014; 189 (08) 947-955
- 30 Fan Y, Gao F, Wu Y, Zhang J, Zhu M, Xiong L. Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis. Crit Care 2016; 20 (01) 338
- 31 Wallace FA, Alexander PD, Spencer C, Naisbitt J, Moore JA, McGrath BA. A comparison of ventilator-associated pneumonia rates determined by different scoring systems in four intensive care units in the North West of England. Anaesthesia 2015; 70 (11) 1274-1280
- 32 McMullen KM, Boyer AF, Schoenberg N, Babcock HM, Micek ST, Kollef MH. Surveillance versus clinical adjudication: differences persist with new ventilator-associated event definition. Am J Infect Control 2015; 43 (06) 589-591
- 33 Lilly CM, Landry KE, Sood RN. , et al; UMass Memorial Critical Care Operations Group; UMass Memorial Critical Care Operations Group. Prevalence and test characteristics of national health safety network ventilator-associated events. Crit Care Med 2014; 42 (09) 2019-2028
- 34 O'Horo JC, Lan H, Thongprayoon C, Schenck L, Ahmed A, Dziadzko M. “Bundle” practices and ventilator-associated events: not enough. Infect Control Hosp Epidemiol 2016; 37 (12) 1453-1457
- 35 Amaral AC, Holder MW. Timing of antimicrobial therapy after identification of ventilator-associated condition is not associated with mortality in patients with ventilator-associated pneumonia: a cohort study. PLoS One 2014; 9 (05) e97575
- 36 Damas P, Frippiat F, Ancion A. , et al. Prevention of ventilator-associated pneumonia and ventilator-associated conditions: a randomized controlled trial with subglottic secretion suctioning. Crit Care Med 2015; 43 (01) 22-30
- 37 Ding S, Kilickaya O, Senkal S, Gajic O, Hubmayr RD, Li G. Temporal trends of ventilator-associated pneumonia incidence and the effect of implementing health-care bundles in a suburban community. Chest 2013; 144 (05) 1461-1468
- 38 Klompas M, Anderson D, Trick W. , et al; CDC Prevention Epicenters. The preventability of ventilator-associated events. Am J Respir Crit Care Med 2015; 191 (03) 292-301
- 39 Kaiser AM, de Jong E, Evelein-Brugman SF, Peppink JM, Vandenbroucke-Grauls CM, Girbes AR. Development of trigger-based semi-automated surveillance of ventilator-associated pneumonia and central line-associated bloodstream infections in a Dutch intensive care. Ann Intensive Care 2014; 4: 40
- 40 Sevransky JE, Checkley W, Herrera P. , et al; United States Critical Illness and Injury Trials Group-Critical Illness Outcomes Study Investigators. Protocols and hospital mortality in critically ill patients: The United States critical illness and injury trials group critical illness outcomes study. Crit Care Med 2015; 43 (10) 2076-2084
- 41 Pronovost PJ, Colantuoni E. Measuring preventable harm: helping science keep pace with policy. JAMA 2009; 301 (12) 1273-1275
- 42 Uçkay I, Ahmed QA, Sax H, Pittet D. Ventilator-associated pneumonia as a quality indicator for patient safety?. Clin Infect Dis 2008; 46 (04) 557-563