PDF herunterladen
Semin intervent Radiol 2017; 34(02): 116-120
DOI: 10.1055/s-0037-1602711
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Yttrium-90 Radioembolization for Metastatic Colorectal Cancer: Outcomes by Number of Lines of Therapy

Andrew Marsala
1   Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at University of California, Los Angeles, California
,
Edward W. Lee
1   Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at University of California, Los Angeles, California
,
Siddharth A. Padia
1   Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at University of California, Los Angeles, California
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
01. Juni 2017 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Abstract

Metastatic colorectal cancer represents the most common liver malignancy, and imparts a very poor prognosis for those who develop this disease. Unlike primary liver tumors such as hepatocellular carcinoma, which largely develops in patients with underlying cirrhosis, most metastatic liver tumor patients have normal underlying liver function. Owing to this, most will succumb to tumoral replacement of the liver rather than from underlying liver dysfunction. Radioembolization represents a treatment modality that can be used in multiple fashions to treat one or both lobes of the liver. Techniques depend on whether the procedure is used as first-line, second/third-line, or as salvage therapy. Outcomes and complications of radioembolization are presented in this article, as well as background information on colorectal cancer and systemic therapies.

Keywords

colorectal cancer - interventional radiology - radioembolization - chemotherapy - transarterial therapy
 

  • References

  • 1 Van Cutsem E, Cervantes A, Adam R. , et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 2016; 27 (08) 1386-1422
    CrossrefPubMedGoogle Scholar
  • 2 Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66 (01) 7-30
    CrossrefPubMedGoogle Scholar
  • 3 Sasson AR, Sigurdson ER. Surgical treatment of liver metastases. Semin Oncol 2002; 29 (02) 107-118
    CrossrefPubMedGoogle Scholar
  • 4 Khatri VP, Chee KG, Petrelli NJ. Modern multimodality approach to hepatic colorectal metastases: solutions and controversies. Surg Oncol 2007; 16 (01) 71-83
    CrossrefPubMedGoogle Scholar
  • 5 Seidensticker R, Denecke T, Kraus P. , et al. Matched-pair comparison of radioembolization plus best supportive care versus best supportive care alone for chemotherapy refractory liver-dominant colorectal metastases. Cardiovasc Intervent Radiol 2012; 35 (05) 1066-1073
    CrossrefPubMedGoogle Scholar
  • 6 Bester L, Meteling B, Pocock N. , et al. Radioembolization versus standard care of hepatic metastases: comparative retrospective cohort study of survival outcomes and adverse events in salvage patients. J Vasc Interv Radiol 2012; 23 (01) 96-105
    CrossrefPubMedGoogle Scholar
  • 7 Alberts SR, Horvath WL, Sternfeld WC. , et al. Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group phase II study. J Clin Oncol 2005; 23 (36) 9243-9249
    CrossrefPubMedGoogle Scholar
  • 8 Nordlinger B, Sorbye H, Glimelius B. , et al; EORTC Gastro-Intestinal Tract Cancer Group; Cancer Research UK; Arbeitsgruppe Lebermetastasen und-tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG); Fédération Francophone de Cancérologie Digestive (FFCD). Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet 2008; 371 (9617): 1007-1016
    CrossrefPubMedGoogle Scholar
  • 9 Benson III AB, Venook AP, Bekaii-Saab T. , et al; National Comprehensive Cancer Network. Colon cancer, version 3.2014. J Natl Compr Canc Netw 2014; 12 (07) 1028-1059
    CrossrefPubMedGoogle Scholar
  • 10 Tournigand C, André T, Achille E. , et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22 (02) 229-237
    CrossrefPubMedGoogle Scholar
  • 11 Hurwitz H, Fehrenbacher L, Novotny W. , et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350 (23) 2335-2342
    CrossrefPubMedGoogle Scholar
  • 12 Giantonio BJ, Catalano PJ, Meropol NJ. , et al; Eastern Cooperative Oncology Group Study E3200. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25 (12) 1539-1544
    CrossrefPubMedGoogle Scholar
  • 13 Goldberg RM, Rothenberg ML, Van Cutsem E. , et al. The continuum of care: a paradigm for the management of metastatic colorectal cancer. Oncologist 2007; 12 (01) 38-50
    CrossrefPubMedGoogle Scholar
  • 14 Hegewisch-Becker S, Graeven U, Lerchenmüller CA. , et al. Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol 2015; 16 (13) 1355-1369
    CrossrefPubMedGoogle Scholar
  • 15 Simkens LH, van Tinteren H, May A. , et al. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group. Lancet 2015; 385 (9980): 1843-1852
    CrossrefPubMedGoogle Scholar
  • 16 Peeters M, Price TJ, Cervantes A. , et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28 (31) 4706-4713
    CrossrefPubMedGoogle Scholar
  • 17 Sobrero AF, Maurel J, Fehrenbacher L. , et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26 (14) 2311-2319
    CrossrefPubMedGoogle Scholar
  • 18 Karapetis CS, Khambata-Ford S, Jonker DJ. , et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359 (17) 1757-1765
    CrossrefPubMedGoogle Scholar
  • 19 Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009; 361 (01) 98-99
    CrossrefPubMedGoogle Scholar
  • 20 Loupakis F, Cremolini C, Salvatore L. , et al. FOLFOXIRI plus bevacizumab as first-line treatment in BRAF mutant metastatic colorectal cancer. Eur J Cancer 2014; 50 (01) 57-63
    PubMedGoogle Scholar
  • 21 Grothey A, Van Cutsem E, Sobrero A. , et al; CORRECT Study Group. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381 (9863): 303-312
    CrossrefPubMedGoogle Scholar
  • 22 Mayer RJ, Van Cutsem E, Falcone A. , et al; RECOURSE Study Group. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med 2015; 372 (20) 1909-1919
    CrossrefPubMedGoogle Scholar
  • 23 Van Cutsem E, Tabernero J, Lakomy R. , et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012; 30 (28) 3499-3506
    CrossrefPubMedGoogle Scholar
  • 24 Lewandowski RJ, Memon K, Mulcahy MF. , et al. Twelve-year experience of radioembolization for colorectal hepatic metastases in 214 patients: survival by era and chemotherapy. Eur J Nucl Med Mol Imaging 2014; 41 (10) 1861-1869
    CrossrefPubMedGoogle Scholar
  • 25 Hickey R, Lewandowski RJ, Prudhomme T. , et al. 90Y radioembolization of colorectal hepatic metastases using glass microspheres: safety and survival outcomes from a 531-patient multicenter study. J Nucl Med 2016; 57 (05) 665-671
    CrossrefPubMedGoogle Scholar
  • 26 Van Hazel G, Blackwell A, Anderson J. , et al. Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. J Surg Oncol 2004; 88 (02) 78-85
    CrossrefPubMedGoogle Scholar
  • 27 Sharma RA, Van Hazel GA, Morgan B. , et al. Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy. J Clin Oncol 2007; 25 (09) 1099-1106
    CrossrefPubMedGoogle Scholar
  • 28 van Hazel GA, Heinemann V, Sharma NK. , et al. SIRFLOX: randomized phase III trial comparing first-line mFOLFOX6 (plus or minus bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer. J Clin Oncol 2016; 34 (15) 1723-1731
    CrossrefPubMedGoogle Scholar
  • 29 Sangha BS, Nimeiri H, Hickey R, Salem R, Lewandowski RJ. Radioembolization as a treatment strategy for metastatic colorectal cancer to the liver: what can we learn from the SIRFLOX trial?. Curr Treat Options Oncol 2016; 17 (06) 26
    CrossrefPubMedGoogle Scholar
  • 30 van Hazel GA, Pavlakis N, Goldstein D. , et al. Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J Clin Oncol 2009; 27 (25) 4089-4095
    CrossrefPubMedGoogle Scholar
  • 31 Mulcahy MF, Lewandowski RJ, Ibrahim SM. , et al. Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres. Cancer 2009; 115 (09) 1849-1858
    CrossrefPubMedGoogle Scholar
  • 32 Hendlisz A, Van den Eynde M, Peeters M. , et al. Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy. J Clin Oncol 2010; 28 (23) 3687-3694
    CrossrefPubMedGoogle Scholar
  • 33 Gil-Alzugaray B, Chopitea A, Iñarrairaegui M. , et al. Prognostic factors and prevention of radioembolization-induced liver disease. Hepatology 2013; 57 (03) 1078-1087
    CrossrefPubMedGoogle Scholar
  • 34 Pieper CC, Willinek WA, Thomas D. , et al. Incidence and risk factors of early arterial blood flow stasis during first radioembolization of primary and secondary liver malignancy using resin microspheres: an initial single-center analysis. Eur Radiol 2016; 26 (08) 2779-2789
    CrossrefPubMedGoogle Scholar
  • 35 Padia SA, Lewandowski RJ, Johnson GE. , et al; Society of Interventional Radiology Standards of Practice Committee. Radioembolization of hepatic malignancies: background, quality improvement guidelines, and future directions. J Vasc Interv Radiol 2017; 28 (01) 1-15
    CrossrefPubMedGoogle Scholar
  • 36 Tamura K, Takada M, Kawase I. , et al. Enhancement of tumor radio-response by irinotecan in human lung tumor xenografts. Jpn J Cancer Res 1997; 88 (02) 218-223
    CrossrefPubMedGoogle Scholar