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Semin Thromb Hemost 2017; 43(07): 699-705
DOI: 10.1055/s-0037-1603366
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Antiplatelet Therapy, Platelet Function Testing, and Bleeding Complications in Cardiac Surgery Patients

Emma C. Hansson
1   Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
2   Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
,
Anders Jeppsson
1   Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
2   Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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Publikationsverlauf

Publikationsdatum:
01. Juni 2017 (online)

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Abstract

Antiplatelet therapy with acetylsalicylic acid, alone or in combination with a P2Y12 inhibitor, reduces thromboembolic events in patients with coronary artery disease but increases the risk for spontaneous and perioperative bleeding complications. Both the antiplatelet effect and the risk for bleeding complications are larger with the new generation P2Y12 inhibitors prasugrel and ticagrelor than with clopidogrel. In this review, the perioperative handling of acetylsalicylic acid and the P2Y12 inhibitors clopidogrel, prasugrel, and ticagrelor will be discussed. In addition, the concept of platelet function testing in the surgical setting will be covered.

Keywords

antiplatelet therapy - acetylsalicylic acid - P2Y12 inhibitors - bleeding - coronary artery bypass grafting - platelet function testing
 

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