Download PDF
AJP Rep 2017; 07(02): e134-e137
DOI: 10.1055/s-0037-1603971
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate

Jennifer Davidson
1   Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee
,
Samantha Polly
2   College of Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee
,
Peter J. Hayes
3   Department of Dermatology, University of Tennessee Health Science Center, Memphis, Tennessee
,
Kristopher R. Fisher
3   Department of Dermatology, University of Tennessee Health Science Center, Memphis, Tennessee
,
Ajay J. Talati
1   Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee
,
Tejesh Patel
3   Department of Dermatology, University of Tennessee Health Science Center, Memphis, Tennessee
› Author Affiliations
Further Information

Publication History

21 February 2017

27 March 2017

Publication Date:
30 June 2017 (online)

Also available at
   Permissions and Reprints

Abstract

Staphylococcal scalded skin syndrome (SSSS) in premature infants is a rare condition. We present SSSS in an extremely low-birth-weight (ELBW) infant with recurrent and confirmed bacterial sepsis. We present it to emphasize the importance for clinicians to not only recognize the clinical manifestations of SSSS, but also the need to closely monitor infants, especially very low-birth-weight (VLBW) and ELBW infants with SSSS for recurrence and bacterial sepsis. SSSS in preterm infants is a potentially lethal condition and early recognition and appropriate supportive care could be life-saving.

Keywords

staphylococcal scalded skin syndrome - neonate - low-birth-weight infant - premature infants
 

  • References

  • 1 Red Book, 30th Edition. 2015. Report on the Committee on Infectious Diseases, 30th Edition. In: Kimberlin DW, Brady MT, Jackson MA, Long SS. eds. Elk Grove Village, IL: American Academy of Pediatric; 2015
    Google Scholar
  • 2 Pollack S. Staphylococcal scalded skin syndrome. Pediatrics in review/American. Acad Pediatr 1996; 17 (01) 18
    PubMedGoogle Scholar
  • 3 Duijsters CE, Halbertsma FJ, Kornelisse RF, Arents NL, Andriessen P. Recurring staphylococcal scalded skin syndrome in a very low birth weight infant: a case report. J Med Case Reports 2009; 3 (01) 7313
    CrossrefPubMedGoogle Scholar
  • 4 Rieger-Fackeldey E, Plano LR, Kramer A, Schulze A. Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants. . Eur J Pediatr 2002; 161 (12) 649-652
    CrossrefPubMedGoogle Scholar
  • 5 Chao SC, Richard G, Lee JY. Netherton syndrome: report of two Taiwanese siblings with staphylococcal scalded skin syndrome and mutation of SPINK5. Br J Dermatol 2005; 152 (01) 159-165
    CrossrefPubMedGoogle Scholar
  • 6 Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR. Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1. J Invest Dermatol 2002; 118 (05) 845-850
    CrossrefPubMedGoogle Scholar
  • 7 Elsner P, Hartmann A. Epidemiology of ETA-Producing and ETB-Producing Staphylococci in Dermatological Patients. Paper presented at: Zentralblatt Fur Bakteriologie Mikrobiologie Und Hygiene Series A-Medical Microbiology Infectious Disease Virology Parasitology 1988
    PubMedGoogle Scholar
  • 8 Saida K, Kawasaki K, Hirabayashi K. , et al. Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants. Eur J Pediatr 2015; 174 (04) 551-555
    CrossrefPubMedGoogle Scholar
  • 9 Ladhani S, Joannou CL. Difficulties in diagnosis and management of the staphylococcal scalded skin syndrome. Pediatr Infect Dis J 2000; 19 (09) 819-821
    CrossrefPubMedGoogle Scholar
  • 10 Elston DM, Stratman EJ, Miller SJ. Skin biopsy: biopsy issues in specific diseases. J Am Acad Dermatol 2016; 74 (01) 1-16 ; quiz 17–18
    CrossrefPubMedGoogle Scholar
  • 11 Long SS, Pickering LK, Prober CG. Principles and practice of pediatric infectious disease. Elsevier Health Sciences; 2012
    Google Scholar
  • 12 Liu C, Bayer A, Cosgrove SE. , et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011; 52 (03) e18-e55 . doi: 10.1093/cid/ciq146
    CrossrefPubMedGoogle Scholar
  • 13 Mockenhaupt M, Idzko M, Grosber M, Schöpf E, Norgauer J. Epidemiology of staphylococcal scalded skin syndrome in Germany. J Invest Dermatol 2005; 124 (04) 700-703
    CrossrefPubMedGoogle Scholar
  • 14 Kapoor V, Travadi J, Braye S. Staphylococcal scalded skin syndrome in an extremely premature neonate: a case report with a brief review of literature. J Paediatr Child Health 2008; 44 (06) 374-376
    CrossrefPubMedGoogle Scholar
  • 15 Dancer SJ, Simmons NA, Poston SM, Noble WC. Outbreak of staphylococcal scalded skin syndrome among neonates. J Infect 1988; 16 (01) 87-103
    CrossrefPubMedGoogle Scholar
  • 16 Hütten M, Heimann K, Baron JM, Wenzl TG, Merk HF, Ott H. Staphylococcal scalded skin syndrome as a harbinger of late-onset staphylococcal septicaemia in a premature infant of very low birth weight. Acta Derm Venereol 2008; 88 (04) 416-417
    PubMedGoogle Scholar
  • 17 Singh SN, Tahazzul M, Singh A, Chandra S. Varicella infection in a neonate with subsequent staphylococcal scalded skin syndrome and fatal shock. BMJ Case Rep 2012; 2012. pii: bcr2012006462
    PubMedGoogle Scholar
  • 18 Hörner A, Hörner R, Salla A. , et al. Staphylococcal scalded skin syndrome in a premature newborn caused by methicillin-resistant Staphylococcus aureus: case report. Sao Paulo Med J 2015; 133 (05) 450-453
    CrossrefPubMedGoogle Scholar
  • 19 Hoffmann R, Lohner M, Böhm N, Schaefer HE, Leititis J. Staphylococcal scalded skin syndrome (SSSS) and consecutive septicaemia in a preterm infant. Pathol Res Pract 1994; 190 (01) 77-81 ; discussion 81–83
    CrossrefPubMedGoogle Scholar
  • 20 Cribier B, Piemont Y, Grosshans E. Staphylococcal scalded skin syndrome in adults. A clinical review illustrated with a new case. J Am Acad Dermatol 1994; 30 (2, Pt 2): 319-324
    CrossrefPubMedGoogle Scholar
  • 21 Ladhani S, Joannou CL, Lochrie DP, Evans RW, Poston SM. Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome. Clin Microbiol Rev 1999; 12 (02) 224-242
    CrossrefPubMedGoogle Scholar
  • 22 Saiman L, Jakob K, Holmes KW. , et al. Molecular epidemiology of staphylococcal scalded skin syndrome in premature infants. Pediatr Infect Dis J 1998; 17 (04) 329-334
    CrossrefPubMedGoogle Scholar
  • 23 Ladhani S. Recent developments in staphylococcal scalded skin syndrome. Clin Microbiol Infect 2001; 7 (06) 301-307
    CrossrefPubMedGoogle Scholar