RSS-Feed abonnieren
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1055/s-0037-1604038
Unusual Presentation of Differentiated Thyroid Cancer Metastasis
Publikationsverlauf
22. März 2017
05. Mai 2017
Publikationsdatum:
14. Juli 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00025477/201802/lookinside/thumbnails/10-1055-s-0037-1604038_170638or-1.jpg)
Abstract
Introduction The rates of thyroid cancers are on a rise, especially well-differentiated thyroid cancers. This could be partly due to newer diagnostic modalities, like high-resolution ultrasound, that can pick up smaller lesions. Differentiated thyroid cancers with distant metastases are not common, and even rarer is the initial presentation with complaints not related to the neck.
Objectives The objective of this series was to study and report the unusual cases of patients with differentiated thyroid cancer with distant metastasis. There is a lack of data in the literature on these cases, and due to the rarity of such metastases, no definite treatment protocol has been defined.
Methods A retrospective chart review of 1,200 cases of thyroid surgeries was performed. A total of 10 cases of well-differentiated thyroid cancer on the final histopathology exam that had initially presented with usual complaints to departments other than the Otolaryngology Department were identified.
Results A total of 6 patients had papillary carcinoma, whereas 4 patients had follicular carcinoma on final the histopathology exam. Two patients presented with iliac crest lesions, 2 with vertebral lesions one each with parapharyngeal mass, supraclavicular mass, labia majora swelling and bleeding, lung, rib and neck of femur lesion.
Conclusion There are still no specific guidelines on how to address these patients with differentiated thyroid cancer with distant metastasis (except for the cases of bone and lung lesions) and on which treatment should be offered in case of recurrence. More studies on the subject are required.
-
References
- 1 Kilfoy BA, Zheng T, Holford TR. , et al. International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control 2009; 20 (05) 525-531
- 2 Enewold L, Zhu K, Ron E. , et al. Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidemiol Biomarkers Prev 2009; 18 (03) 784-791
- 3 Madani A, Jozaghi Y, Tabah R, How J, Mitmaker E. Rare metastases of well-differentiated thyroid cancers: a systematic review. Ann Surg Oncol 2015; 22 (02) 460-466
- 4 Song H-J, Xue Y-L, Xu Y-H, Qiu Z-L, Luo Q-Y. Rare metastases of differentiated thyroid carcinoma: pictorial review. Endocr Relat Cancer 2011; 18 (05) R165-R174
- 5 Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]. Cancer 1998; 83 (12) 2638-2648
- 6 Hardin H, Montemayor-Garcia C, Lloyd RV. Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers. Hum Pathol 2013; 44 (09) 1707-1713
- 7 Kloos RT, Mazzaferri EL. A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab 2005; 90 (09) 5047-5057
- 8 Haugen BR, Kane MA. Approach to the thyroid cancer patient with extracervical metastases. J Clin Endocrinol Metab 2010; 95 (03) 987-993
- 9 Lee J, Soh E-Y. Differentiated thyroid carcinoma presenting with distant metastasis at initial diagnosis clinical outcomes and prognostic factors. Ann Surg 2010; 251 (01) 114-119
- 10 Haugen BR, Alexander EK, Bible KC. , et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26 (01) 1-133