Prenatal Therapy with Magnesium Sulfate and Its Correlation with Neonatal Serum Magnesium Concentration

L. García Alonso; M. Pumarada Prieto; E. González Colmenero; A. Concheiro Guisán; M. Suárez Albo; C. Durán Fernández-Feijoo; L. González Durán; J. R. Fernández Lorenzo

doi:10.1055/s-0037-1606358

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2018; 35(02): 170-176
DOI: 10.1055/s-0037-1606358

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Prenatal Therapy with Magnesium Sulfate and Its Correlation with Neonatal Serum Magnesium Concentration

Autoren

L. García Alonso

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
M. Pumarada Prieto

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
E. González Colmenero

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
A. Concheiro Guisán

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
M. Suárez Albo

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
C. Durán Fernández-Feijoo

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
L. González Durán

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain
J. R. Fernández Lorenzo

¹Department of Pediatrics, Álvaro Cunqueiro University Hospital, Vigo, Galicia, Spain

Abstract

Introduction Antenatal magnesium sulfate (MgSO₄) administration has shown to be effective in minimizing cerebral palsy and severe motor dysfunction at the age of 2 years. The aim of this study is to determine the relationship between the magnesium dose delivered to the mother and the magnesium concentration in the neonates.

Materials and Methods A prospective cohort study was conducted on neonates of less than 32 weeks' gestation admitted to the neonatal intensive care unit of University Hospital Complex of Vigo from December 2012 to July 2015. Comparative analysis of magnesium levels between the groups of neonates exposed to MgSO₄ and the control group.

Results A total of 118 neonates were included in the study. The mothers of 62 of them had received MgSO₄ as a neuroprotective agent. There was a significant correlation between the full dose of MgSO₄ received by the mother and the levels of magnesium in the neonate in the first 24 hours of life (r ² = 0.397; p < 0.001).

Conclusion The MgSO₄ dose received by the mother has a linear relationship with the magnesium levels obtained in neonates.

Keywords

magnesium sulfate - neuroprotection - serum magnesium concentration - maternal dose

Volltext

Referenzen

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