The Clinician's Toolkit: Laboratory Tests in the Diagnosis of Childhood Tuberculosis Infection and Disease

Heather Young Highsmith; Anna Maria Mandalakas

doi:10.1055/s-0037-1607232

Journal of Pediatric Infectious Diseases, Inhaltsverzeichnis

J Pediatr Infect Dis 2018; 13(02): 122-131
DOI: 10.1055/s-0037-1607232

Review Article

Georg Thieme Verlag KG Stuttgart · New York

The Clinician's Toolkit: Laboratory Tests in the Diagnosis of Childhood Tuberculosis Infection and Disease

Authors

Heather Young Highsmith

¹Division of Infectious Diseases, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for the Medical Sciences, Arkansas

²Global TB Program, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States
Anna Maria Mandalakas

²Global TB Program, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States

³Section on Global and Immigrant Health, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States

Abstract

Smear microscopy and culture—the mainstay of tuberculosis (TB) diagnostics for the past century—fail to diagnose the majority of childhood TB cases. Promising new tests are becoming rapidly available, but their utility in childhood TB fails to surpass the accuracy of an astute clinician. In this review, we detail conventional and newer tests available for the diagnosis of TB infection and TB disease and their use in children, as well as potential others in development.

Keywords

Mycobacterium tuberculosis - latent tuberculosis - pulmonary tuberculosis - pediatrics

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References
1 WHO. Global Tuberculosis Report 2016. Geneva: World Health Organization; 2016
2 Bacha JM, Ngo K, Clowes P. , et al. Why being an expert - despite xpert - remains crucial for children in high TB burden settings. BMC Infect Dis 2017; 17 (01) 123
3 Pai M, Behr MA, Dowdy D. , et al. Tuberculosis. Nat Rev Dis Primers 2016; 2: 16076
4 Cruz AT, Starke JR. Clinical manifestations of tuberculosis in children. Paediatr Respir Rev 2007; 8 (02) 107-117
5 Oliwa JN, Karumbi JM, Marais BJ, Madhi SA, Graham SM. Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: a systematic review. Lancet Respir Med 2015; 3 (03) 235-243
6 Chintu C, Mudenda V, Lucas S. , et al; UNZA-UCLMS Project Paediatric Post-mortem Study Group. Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study. Lancet 2002; 360 (9338): 985-990
7 Nantongo JM, Wobudeya E, Mupere E. , et al. High incidence of pulmonary tuberculosis in children admitted with severe pneumonia in Uganda. BMC Pediatr 2013; 13: 16
8 WHO. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. Geneva: World Health Organization; 2014
9 Cheng TL, Ottolini M, Getson P, Wolf MD, Scheidt PC. Poor validity of parent reading of skin test induration in a high risk population. Pediatr Infect Dis J 1996; 15 (01) 90-92
10 Mahairas GG, Sabo PJ, Hickey MJ, Singh DC, Stover CK. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol 1996; 178 (05) 1274-1282
11 Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 1996; 64 (01) 16-22
12 Andersen P, Munk ME, Pollock JM, Doherty TM. Specific immune-based diagnosis of tuberculosis. Lancet 2000; 356 (9235): 1099-1104
13 Connell TG, Rangaka MX, Curtis N, Wilkinson RJ. QuantiFERON-TB Gold: state of the art for the diagnosis of tuberculosis infection?. Expert Rev Mol Diagn 2006; 6 (05) 663-677
14 Lalvani A, Pathan AA, McShane H. , et al. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am J Respir Crit Care Med 2001; 163 (04) 824-828
15 Mandalakas AM, Detjen AK, Hesseling AC, Benedetti A, Menzies D. Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis. Int J Tuberc Lung Dis 2011; 15 (08) 1018-1032
16 Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y. , et al. The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis. Pediatr Infect Dis J 2011; 30 (08) 694-700
17 Mandalakas AM, Kirchner HL, Walzl G. , et al. Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting. Am J Respir Crit Care Med 2015; 191 (07) 820-830
18 Petruccioli E, Chiacchio T, Pepponi I. , et al. First characterization of the CD4 and CD8 T-cell responses to QuantiFERON-TB Plus. J Infect 2016; 73 (06) 588-597
19 Barcellini L, Borroni E, Brown J. , et al. First independent evaluation of QuantiFERON-TB Plus performance. Eur Respir J 2016; 47 (05) 1587-1590
20 Sakula A. Robert Koch: centenary of the discovery of the tubercle bacillus, 1882. Thorax 1982; 37 (04) 246-251
21 Procop GW. Laboratory diagnosis and susceptibility testing for Mycobacterium tuberculosis . Microbiol Spectr 2016 ;4(6)
22 Hesseling AC, Cotton MF, Jennings T. , et al. High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies. Clin Infect Dis 2009; 48 (01) 108-114
23 Grisaru-Soen G, Savyon M, Sadot E. , et al. Congenital tuberculosis and management of exposure in neonatal and pediatric intensive care units. Int J Tuberc Lung Dis 2014; 18 (09) 1062-1065
24 Kunkel A, Abel Zur Wiesch P, Nathavitharana RR, Marx FM, Jenkins HE, Cohen T. Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis. BMC Infect Dis 2016; 16: 282
25 Marais BJ, Brittle W, Painczyk K. , et al. Use of light-emitting diode fluorescence microscopy to detect acid-fast bacilli in sputum. Clin Infect Dis 2008; 47 (02) 203-207
26 Chaisson LH, Reber C, Phan H. , et al. Evaluation of mobile digital light-emitting diode fluorescence microscopy in Hanoi, Viet Nam. Int J Tuberc Lung Dis 2015; 19 (09) 1068-1072
27 Oberhelman RA, Soto-Castellares G, Caviedes L. , et al. Improved recovery of Mycobacterium tuberculosis from children using the microscopic observation drug susceptibility method. Pediatrics 2006; 118 (01) e100-e106
28 Tran ST, Renschler JP, Le HT. , et al. Diagnostic accuracy of microscopic Observation Drug Susceptibility (MODS) assay for pediatric tuberculosis in Hanoi, Vietnam. PLoS One 2013; 8 (09) e72100
29 WHO. Noncommercial Culture and Drug-Susceptibility Testing Methods for Screening Patients at Risk for Multidrug-Resistant Tuberculosis: Policy Statement. Geneva: WHO Press; 2011
30 Battaglioli T, Rintiswati N, Martin A. , et al. Comparative performance of Thin Layer Agar and Löwenstein-Jensen culture for diagnosis of tuberculosis. Clin Microbiol Infect 2013; 19 (11) E502-E508
31 Leung E, Minion J, Benedetti A, Pai M, Menzies D. Microcolony culture techniques for tuberculosis diagnosis: a systematic review. Int J Tuberc Lung Dis 2012; 16 (01) 16-23 , i–iii i–iii
32 Rapid diagnostic tests for tuberculosis: what is the appropriate use? American Thoracic Society Workshop. Am J Respir Crit Care Med 1997; 155 (05) 1804-1814
33 Delacourt C, Poveda JD, Chureau C. , et al. Use of polymerase chain reaction for improved diagnosis of tuberculosis in children. J Pediatr 1995; 126 (5 Pt 1): 703-709
34 Gomez-Pastrana D, Torronteras R, Caro P. , et al. Comparison of amplicor, in-house polymerase chain reaction, and conventional culture for the diagnosis of tuberculosis in children. Clin Infect Dis 2001; 32 (01) 17-22
35 Smith KC, Starke JR, Eisenach K, Ong LT, Denby M. Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction. Pediatrics 1996; 97 (02) 155-160
36 Detjen AK, DiNardo AR, Leyden J. , et al. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med 2015; 3 (06) 451-461
37 Nicol MP, Workman L, Isaacs W. , et al. Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Lancet Infect Dis 2011; 11 (11) 819-824
38 Zar HJ, Workman L, Isaacs W, Dheda K, Zemanay W, Nicol MP. Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective study. Lancet Glob Health 2013; 1 (02) e97-e104
39 Zar HJ, Workman L, Isaacs W. , et al. Rapid molecular diagnosis of pulmonary tuberculosis in children using nasopharyngeal specimens. Clin Infect Dis 2012; 55 (08) 1088-1095
40 Boyles TH, Hughes J, Cox V, Burton R, Meintjes G, Mendelson M. False-positive Xpert® MTB/RIF assays in previously treated patients: need for caution in interpreting results. Int J Tuberc Lung Dis 2014; 18 (07) 876-878
41 WHO. The use of molecular line probe assay for the detection of resistance to second-line anti-tuberculosis drugs. Expert Group Meeting Report. 2013
42 Musial CE, Tice LS, Stockman L, Roberts GD. Identification of mycobacteria from culture by using the Gen-Probe Rapid Diagnostic System for Mycobacterium avium complex and Mycobacterium tuberculosis complex. J Clin Microbiol 1988; 26 (10) 2120-2123
43 WHO. The Use of Loop-Mediated Isothermal Amplification (TB-LAMP) for the Diagnosis of Pulmonary Tuberculosis: Policy Guidance. Geneva: WHO; 2016
44 WHO. The Use of Lateral Flow Urine Lipoarabinomannan Assay (LF-LAM) for the Diagnosis and Screening of Active Tuberculosis in People Living with HIV. Geneva: WHO; 2015
45 Jones-López EC, Acuña-Villaorduña C, Ssebidandi M. , et al. Cough aerosols of Mycobacterium tuberculosis in the prediction of incident tuberculosis disease in household contacts. Clin Infect Dis 2016; 63 (01) 10-20
46 Phillips M, Basa-Dalay V, Blais J. , et al. Point-of-care breath test for biomarkers of active pulmonary tuberculosis. Tuberculosis (Edinb) 2012; 92 (04) 314-320
47 Kolk A, Hoelscher M, Maboko L. , et al. Electronic-nose technology using sputum samples in diagnosis of patients with tuberculosis. J Clin Microbiol 2010; 48 (11) 4235-4238
48 Reither K, Jugheli L, Glass TR. , et al. Evaluation of giant African pouched rats for detection of pulmonary tuberculosis in patients from a high-endemic setting. PLoS One 2015; 10 (10) e0135877
49 Mahoney A, Weetjens BJ, Cox C. , et al. Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction. Tuberc Res Treat 2012; 2012: 716989
50 Tuberculosis AAP. . In: Kimberlin DW, Brady MT, Jackson MA, Long SS. , eds. Red Book: 2015 Report of the Committee on Infectious Diseases, Elk Grove Village, IL: American Academy of Pediatrics; 2015: 805-831
51 Marais BJ, Gie RP, Schaaf HS. , et al. The clinical epidemiology of childhood pulmonary tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 2004; 8 (03) 278-285