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Semin Liver Dis 2017; 37(04): 363-376
DOI: 10.1055/s-0037-1607451
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Multifunctional YY1 in Liver Diseases

Mengjie Zhang   *
1   Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Yi Zhang   *
3   Department of Clinical Laboratory, 150th Hospital of People's Liberation Army (PLA), Luoyang, China
,
Shuang Yang
4   People's Hospital of Zunyi City, Bozhou District, Zunyi, China
,
Jian Zhou
1   Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Weiwu Gao
1   Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Xia Yang
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Di Yang
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Zhiqiang Tian
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Yuzhang Wu
2   Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China
,
Bing Ni
1   Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China
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Publikationsverlauf

Publikationsdatum:
22. Dezember 2017 (online)

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Abstract

The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the cellular context. While YY1 is ubiquitously expressed and highly conserved between species, its role varies among the diverse cell types and includes proliferation, differentiation, and apoptosis. Upregulated YY1 expression is found in pathogenic conditions, such as human hepatocellular carcinoma and hepatitis B virus infection, and its roles in the molecular pathogenic mechanisms in liver (i.e., fibrosis, carcinogenesis, viral-induced injury) are currently being elucidated. The most recent studies have revealed that YY1 is deeply involved in such dysregulated cellular metabolisms as glycometabolism, lipid metabolism, and bile acid metabolism, which are all involved in various diseases. In this review, we will summarize the current knowledge on YY1 in liver diseases, providing a focused discussion on the characterized and probable underlying mechanisms, as well as a reasoned evaluation of the potential for YY1-mediated pathology as drug targets in liver disease therapies.

Keywords

YY1 - viral hepatitis - liver fibrosis - hepatocellular carcinoma - cancer - metabolism

* Authors contributed equally to this work.


 

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