Polyketides and Anti-inflammatory Activities of the Endophytic Fungus Aspergillus ochraceopetaliformis Isolated from Anthurium brownii

The genus Aspergillus contains a large number of diverse species, and can produce a variety of secondary metabolites [1]. Natural products isolated from Aspergillus are usually nitrogen containing ingredients which demonstrated cytotoxic, antimicrobial, antioxidant and insecticidal activities [2]. Therefore, fungus belonging to Aspergillus genus is regarded as an interesting research topic for new drug development. In the current research, six new polyketides, named asperochralactone A–D (1–4), isoaspyronol (5), 8-demethylaspyronol (6), together with eleven known polyketides 7–17, were isolated from the ethyl acetate layer of the endophyte Aspergillus ochraceopetaliformis Bat. & Maia (Trichocomaceae), which was isolated and cultured from the leaves of Anthurium brownii Mast. (Araceae). The structures of these compounds were determined by spectroscopic methods, and the relative configurations of the new compounds were elucidated especially by the information of their proton coupling constants and NOESY spectra. Furthermore, the absolute configurations were determined by circular dichroism spectrum (CD) and electronic circular dichroism (ECD) analyses. All isolates were evaluated for anti-inflammatory and cytotoxic activities.

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[1] Frisvad JC, Larsen TO. Appl Microbiol Biotechnol 2015; 99: 7859 – 7877

[2] Zhao C, Liu H, Zhu W. Acta Microbiologica Sinica 2016; 56: 331 – 362