Chemical constituents from the groundnuts of Apios americana

Phytochemical investigation of the groundnuts of Apios americana has resulted in the isolation of three new isoflavonoids (1–3) along with seventeen known compounds (4–20) by chromatographic separation methods [1 – 5]. The structures of all compounds were elucidated by spectroscopic methods including 1D-NMR (¹H, ¹³C), 2D-NMR (DEPT, HSQC, COSY, HMBC, and NOESY), and HRESIMS. The absolute configuration of chiral centers in compound 1 was determined by electronic circular dichroism (ECD) study. Three of these compounds (4, 5, and 20) were identified in and isolated from this species for the first time. Biological activities of the compounds (1–20) were also evaluated in this study.

[1] Ichige M, Fukuda E, Miida S, Hattan J, Misawa N, Saito S, Fujimaki T, Imoto M, Shindo K. J Agric Food Chem 2013; 61: 2183 – 2187

[2] Haruna K, Koda M, Saito S, Imoto M, Kawada M, Yamazaki Y, Momose I, Shindo K. Biosci Biotech Biochem 2016; 80: 774 – 778

[3] Zhao S, Zhang L, Gao P, Shao Z. Food Chem 2009; 114: 869 – 873

[4] Selepe MA, Drewes SE, van Heerden FR. Tetrahedron 2011; 67: 8654 – 8658

[5] Shibuya Y, Tahara S, Kimura Y, Mizutani J. J Biosci 1991; 46: 513 – 518