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Am J Perinatol 2018; 35(05): 434-440
DOI: 10.1055/s-0037-1608660
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model

Selçuk Yazıcı
1   Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkey
,
Cansu Unden Ozcan
2   Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey
,
Adnan Adil Hismiogullari
3   Department of Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey
,
Fatma Bahar Sunay
4   Department of Histology and Embryology, Faculty of Medicine, Balikesir University, Balikesir, Turkey
,
Teoman Ozcan
2   Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey
,
Emel Ataş Berksoy
5   Department of Pediatrics, Dr Behçet Uz Pediatric Hospital, İzmir, Turkey
,
Elif Aksoz
6   Department of Pharmacology, Faculty of Medicine, Balikesir University, Balikesir, Turkey
› Author Affiliations
Further Information

Publication History

01 March 2017

06 October 2017

Publication Date:
13 November 2017 (online)

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Abstract

Introduction Necrotizing enterocolitis (NEC) is one of the major health problems of newborn period. To date, a large amount of chemicals have been tested for NEC and some showed limited beneficial effects. The research for better results still continues. This study aims to investigate the effects of quercetin (QE) on NEC treatment in rats.

Methods Newborn rats were divided into control, NEC, and NEC + QE groups. In NEC and NEC + QE groups, experimental NEC was induced. NEC + QE group animals were also given QE. Weight changes of the animals were recorded, and serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), and glutathione (GSH) levels were measured. Histologic evaluation of the distal ileum and the terminal deoxynucleotidyl transferase dUTP nick end labeling staining were performed.

Results A significant increase in the TAS levels was observed in NEC + QE group. Only NEC group exhibited significantly higher TOS and MDA levels and lower GSH levels. Rats in the NEC + QE group had better histopathology and less apoptosis than NEC group.

Conclusion QE is effective in enhancing antioxidant defense mechanism, limiting oxidative stress, reducing intestinal damage, and preventing NEC development.

Keywords

quercetin - necrotizing enterocolitis - newborn - rat
 

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