Regenerative Medicine/Cardiac Cell Therapy: Pluripotent Stem Cells

Ana G. Duran; Olivia Reidell; Harald Stachelscheid; Kristin Klose; Manfred Gossen; Volkmar Falk; Wilhelm Röll; Christof Stamm

doi:10.1055/s-0037-1608761

The Thoracic and Cardiovascular Surgeon, Table of Contents

Thorac Cardiovasc Surg 2018; 66(01): 053-062
DOI: 10.1055/s-0037-1608761

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Regenerative Medicine/Cardiac Cell Therapy: Pluripotent Stem Cells

Authors

Ana G. Duran

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany
Olivia Reidell

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany
Harald Stachelscheid

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany

²Berlin Institute of Health, Berlin, Germany
Kristin Klose

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany
Manfred Gossen

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany
Volkmar Falk

³DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany

⁴Deutsches Herzzentrum Berlin, Berlin, Germany
Wilhelm Röll

⁵Klinik für Herzchirurgie, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen Germany
Christof Stamm

¹Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany

³DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany

⁴Deutsches Herzzentrum Berlin, Berlin, Germany

Abstract

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Abstract

For more than 20 years, tremendous efforts have been made to develop cell-based therapies for treatment of heart failure. However, the results of clinical trials using somatic, nonpluripotent stem or progenitor cells have been largely disappointing in both cardiology and cardiac surgery scenarios. Surgical groups were among the pioneers of experimental and clinical myocyte transplantation (“cellular cardiomyoplasty”), but little translational progress was made prior to the development of cellular reprogramming for creation of induced pluripotent stem cells (iPSC). Ever since, protocols have been developed which allow for the derivation of large numbers of autologous cardiomyocytes (CMs) from patient-specific iPSC, moving translational research closer toward clinical pilot trials. However, compared with somatic cell therapy, the technology required for safe and efficacious pluripotent stem cell (PSC)-based therapies is extremely complex and requires tremendous resources and close interactions between basic scientists and clinicians. This review summarizes PSC sources, strategies to derive CMs, current cardiac tissue engineering approaches, concerns regarding immunogenicity and cellular maturity, and highlights the contributions made by surgical groups.

Keywords

cell - biology - culture - experimental - stem cells - heart failure - tissue engineering

Full Text

References

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