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Synthesis 2018; 50(16): 3238-3242
DOI: 10.1055/s-0037-1609481
DOI: 10.1055/s-0037-1609481
special topic
Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions
Further Information
Publication History
Received: 31 December 2017
Accepted after revision: 13 March 2018
Publication Date:
16 April 2018 (online)
§ These authors contributed equally to this work.
Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis
Abstract
A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609481.
- Supporting Information
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