Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates

Sandip Murarka; Andrey P. Antonchick

doi:10.1055/s-0037-1609715

Synthesis, Table of Contents

Synthesis 2018; 50(11): 2150-2162
DOI: 10.1055/s-0037-1609715

short review

Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates

Authors

Sandip Murarka*

^aDepartment of Chemistry, Indian Institute of Technology Jodhpur, NH-65, Nagaur Road, Karwar-342037, Jodhpur District, Rajasthan, India Email: sandipmurarka@iitj.ac.in
Andrey P. Antonchick*

^bAbteilung für Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44227 Dortmund, Germany Email: andrey.antonchick@mpi-dortmund.mpg.de

^cFakultät Chemie und Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 4a, 44227 Dortmund, Germany

Abstract

All articles of this category

Abstract

Recent years have witnessed a significant advancement in the field of radical oxidative coupling of ketones towards the synthesis of highly useful synthetic building blocks, such as 1,4-dicarbonyl compounds, and biologically important heterocyclic and carbocyclic compounds. Besides oxidative homo- and cross-coupling of enolates, other powerful methods involving direct C(sp³)–H functionalizations of ketones have emerged towards the synthesis of 1,4-dicarbonyl compounds. Moreover, direct α-C–H functionalization of ketones has also allowed an efficient access to carbocycles and heterocycles. This review summarizes all these developments made since 2008 in the field of metal-catalyzed/promoted radical-mediated functionalization of ketones at the α-position.

1 Introduction

2 Synthesis of 1,4-Dicarbonyl Compounds

3 Synthesis of Heterocyclic Scaffolds

4 Synthesis of Carbocyclic Scaffolds

5 Conclusion

Key words

ketone - oxidative coupling - C–H functionalization - cross-dehydrogenative coupling - radical

Full Text

References

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