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Synthesis 2018; 50(11): 2150-2162
DOI: 10.1055/s-0037-1609715
DOI: 10.1055/s-0037-1609715
short review
Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates
A.P.A. acknowledges the support of DFG (Heisenberg scholarship AN 1064/4-1) and Boehringer Ingelheim Foundation (Plus 3).Further Information
Publication History
Received: 25 February 2018
Accepted after revision: 21 March 2018
Publication Date:
03 May 2018 (online)
Abstract
Recent years have witnessed a significant advancement in the field of radical oxidative coupling of ketones towards the synthesis of highly useful synthetic building blocks, such as 1,4-dicarbonyl compounds, and biologically important heterocyclic and carbocyclic compounds. Besides oxidative homo- and cross-coupling of enolates, other powerful methods involving direct C(sp3)–H functionalizations of ketones have emerged towards the synthesis of 1,4-dicarbonyl compounds. Moreover, direct α-C–H functionalization of ketones has also allowed an efficient access to carbocycles and heterocycles. This review summarizes all these developments made since 2008 in the field of metal-catalyzed/promoted radical-mediated functionalization of ketones at the α-position.
1 Introduction
2 Synthesis of 1,4-Dicarbonyl Compounds
3 Synthesis of Heterocyclic Scaffolds
4 Synthesis of Carbocyclic Scaffolds
5 Conclusion
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