Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines

Published as part of the Special Topic Photoredox Methods and their Strategic Applications in Synthesis

Abstract

A strategy has been described to synthesize β,γ-diamino­ketones. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes, enamides, and O-acylhydroxylamines in DMSO. Four bonds (one C–C, one C–N, and two C–O) are constructed in a single operation. Various functionalized vicinal diamines have been furnished by the radical relay reaction.

Key words

photochemistry - ketones - nitrogen-centered radicals - cascade reactions - vicinal diamines

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