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Synthesis 2019; 51(02): 516-521
DOI: 10.1055/s-0037-1609937
DOI: 10.1055/s-0037-1609937
paper
Na2CO3-Catalyzed N-Acylation of Indoles with Alkenyl Carboxylates
The work was supported by the Youth Science and Technology Talent Development Project in Education Department of Guizhou Province (Grant No. qianjiaohe KY zi [2017] number 261) and Innovation Team of Liupanshui Normal University (Grant No. LPSSYKJTD201601).Further Information
Publication History
Received: 07 June 2018
Accepted after revision: 04 August 2018
Publication Date:
04 September 2018 (online)
Abstract
The N-acylation of indoles has been accomplished via inorganic base catalysis. It provided an efficient and simple catalysis system for the preparation of N-acylindoles with alkenyl carboxylates as acylating agents. A broad variety of indoles undergo the smooth N-acylation using Na2CO3 as catalyst in MeCN at 120 °C to give the corresponding N-acylindoles in good to excellent yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609937.
- Supporting Information
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