Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Weiye Guan; Jennie Liao; Mary P. Watson

doi:10.1055/s-0037-1610084

Synthesis, Inhaltsverzeichnis

Synthesis 2018; 50(16): 3231-3237
DOI: 10.1055/s-0037-1610084

special topic

Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts

Weiye Guan

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu

,

Jennie Liao

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu

,

Mary P. Watson *

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA eMail: mpwatson@udel.edu

› Institutsangaben

Abstract

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^‡ W.G. and J.L. are co-first authors.

Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis

Abstract

Cross-couplings of benzylic pyridinium salts and vinylboronic acids or esters have been developed. Via benzylic pyridinium intermediates, benzylic amines can be engaged in these cross-couplings through C–N bond functionalization. This method boasts mild reaction conditions and excellent tolerance for heteroaryl substituents and a range of functional groups.

Key words

allyl complexes - amines - benzylation - catalysis - cross-coupling - nickel

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Referenzen

References

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