Recent Developments in Visible-Light-Catalyzed Multicomponent Trifluoromethylation of Unsaturated Carbon–Carbon Bonds

Eun Hye Oh; Hyun Jin Kim; Soo Bong Han

doi:10.1055/s-0037-1610085

Synthesis, Table of Contents

Synthesis 2018; 50(17): 3346-3358
DOI: 10.1055/s-0037-1610085

special topic

Recent Developments in Visible-Light-Catalyzed Multicomponent Trifluoromethylation of Unsaturated Carbon–Carbon Bonds

Eun Hye Oh

^aDivision of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea Email: sbhan@krict.re.kr

^bDepartment of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02481, Republic of Korea

,

Hyun Jin Kim*

^aDivision of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea Email: sbhan@krict.re.kr

,

Soo Bong Han *

^aDivision of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea Email: sbhan@krict.re.kr

^cDepartment of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 217 Gajeongro, Yuseong, Daejeon, 34113, Republic of Korea

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Abstract

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Published as part of the Special Topic Photoredox Methods and their Strategic Applications in Synthesis

Abstract

Trifluoromethylation has emerged as an important tool for modulating the molecular chemical and physical properties in material, polymer, and medicinal chemistry. In particular, photocatalyzed trifluoromethylation in the presence of visible-light irradiation has potentially different activity under mild conditions compared with traditional methods. This review summarizes the recent advances in trifluoromethylation with multiple bond system such as alkynes and alkenes.

1 Introduction

2 Trifluoromethylating Reagents

3 Multicomponent Reactions of Alkynes

4 Multicomponent Reactions of Alkenes

5 Conclusion

Key words

trifluoromethyl - radical - alkene - alkyne - photocatalyst - visible light

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References

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