α-Arylation of Esters and Ketones Enabled by a Bench-Stable Pd(I) Dimer Catalyst

Theresa Sperger; Franziska Schoenebeck

doi:10.1055/s-0037-1610087

Synthesis, Table of Contents

Synthesis 2018; 50(22): 4471-4475
DOI: 10.1055/s-0037-1610087

paper

α-Arylation of Esters and Ketones Enabled by a Bench-Stable Pd(I) Dimer Catalyst

Theresa Sperger

,

Franziska Schoenebeck *

Abstract

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Published as part of the Special Section dedicated to Scott E. Denmark on the occasion of his 65^th birthday

Abstract

A procedure for the α-arylation of α,α-disubstituted esters and ketones to generate quaternary carbon centers is described. The developed protocol is operationally simple and employs an air- and moisture-stable dinuclear Pd(I) complex [Pd(μ-I)(Pt-Bu₃)]₂ to mediate selective α-arylation of aromatic C–I/Br bonds in the presence of aromatic C–Cl and/or C–OTf sites.

Key words

Pd(I) dimer - air-stable Pd catalyst - quaternary carbon - cross-coupling

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References

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