Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Jamie A. Leitch; Christopher G. Frost

doi:10.1055/s-0037-1610142

Synthesis, Table of Contents

Synthesis 2018; 50(14): 2693-2706
DOI: 10.1055/s-0037-1610142

short review

Regioselective Transition-Metal-Catalyzed C–H Functionalization of Anilines

Jamie A. Leitch*

Department of Chemistry, University of Bath, Claverton Down, Somerset, BA2 7AY, UK Email: j.leitch@bath.ac.uk Email: c.g.frost@bath.ac.uk

,

Christopher G. Frost*

Department of Chemistry, University of Bath, Claverton Down, Somerset, BA2 7AY, UK Email: j.leitch@bath.ac.uk Email: c.g.frost@bath.ac.uk

› Author Affiliations

Abstract

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Abstract

Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful tool to derivatize biologically relevant molecules. To this end, the derivation of anilines via catalytic C–H functionalization has been the subject of important new synthetic methodology. This review focuses on the tactics used to allow regioselective C–H functionalization of anilines.

1 Introduction

2 ortho-Selective C–H Functionalization

2.1 Palladium

2.2 Rhodium

2.3 Ruthenium

2.4 Nickel

3 meta-Selective C–H Functionalization

4 para-Selective C–H Functionalization

5 Conclusion

Key words

C–H functionalization - homogeneous catalysis - anilines - regioselectivity - aromatic

Full Text

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