Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives

Iuliia A. Gracheva; Elena V. Svirshchevskaya; Vladimir I. Faerman; Irina P. Beletskaya; Alexey Yu. Fedorov

doi:10.1055/s-0037-1610146

Synthesis, Inhaltsverzeichnis

Synthesis 2018; 50(14): 2753-2760
DOI: 10.1055/s-0037-1610146

paper

Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives

Iuliia A. Gracheva

^aDepartment of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation eMail: afnn@rambler.ru

,

Elena V. Svirshchevskaya

^bLaboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russian Federation

,

Vladimir I. Faerman

^aDepartment of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation eMail: afnn@rambler.ru

,

Irina P. Beletskaya

^cDepartment of Chemistry, M. V. Lomonosov Moscow State University, 1-3 Leninskiye Gory, 119992 Moscow, Russian Federation

,

Alexey Yu. Fedorov*

^aDepartment of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation eMail: afnn@rambler.ru

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Abstract

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Abstract

Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T₃M₄, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.

Key words

antitumor agents - colchicine - allocolchicine - tubulin - bifunctional derivatives

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References

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