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Synthesis 2018; 50(17): 3430-3435
DOI: 10.1055/s-0037-1610170
DOI: 10.1055/s-0037-1610170
paper
Indium-, Magnesium-, and Zinc-Mediated Debenzylation of Protected 1H-Tetrazoles: A Comparative Study
This work was financially supported by the Agence National pour le Développement de la Reserch en Santé (Algérie) and the Spanish Ministerio de Ciencia e Innovación (CTQ2011-24155, CTQ2011-24165), the Ministerio de Economía y Competitividad (CTQ2013-43446-P, CTQ2014-51912-REDC, CTQ2014-53695-P, CTQ2017-85093-P), FEDER, the Generalitat Valenciana (PROMETEO 2009/039, PROMETEOII 2014/017), and the University of Alicante. We also thank the Spanish Ministerio de Asuntos Exteriores y de Cooperación (AP/039112/11).Further Information
Publication History
Received: 31 March 2018
Accepted after revision: 30 April 2018
Publication Date:
25 June 2018 (online)
Dedicated to Professor Vicente Gotor on the occasion of his retirement
Abstract
5-Substituted 1-benzyltetrazoles are easily debenzylated to give the corresponding deprotected tetrazoles using dissolved metals under protic conditions: Mg/MeOH, In/MeOH, or Zn/MeCO2H are the procedures of choice for this transformation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610170.
- Supporting Information
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