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Synthesis 2018; 50(24): 4963-4981
DOI: 10.1055/s-0037-1610223
DOI: 10.1055/s-0037-1610223
paper
Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions
Further Information
Publication History
Received: 14 May 2018
Accepted after revision: 04 July 2018
Publication Date:
20 August 2018 (online)
Abstract
Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.
Key words
multicomponent reaction - combinatorial chemistry - isoquinolines - indoles - sulfonamidesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610223.
- Supporting Information
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