Synthesis, Table of Contents Synthesis 2019; 51(02): 421-432DOI: 10.1055/s-0037-1610274 paper © Georg Thieme Verlag Stuttgart · New York A General Protocol for the Synthesis of H-α-Hydroxyphosphinates Jade Dussart , Julia Deschamp * Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, 93017 Bobigny Cedex, France Email: julia.deschamp@univ-paris13.fr Email: marc.lecouvey@univ-paris13.fr , Maelle Monteil , Olivier Gager , Evelyne Migianu-Griffoni , Marc Lecouvey* Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS UMR 7244, 93017 Bobigny Cedex, France Email: julia.deschamp@univ-paris13.fr Email: marc.lecouvey@univ-paris13.fr › Author Affiliations Recommend Article Abstract Buy Article All articles of this category Abstract A general synthetic procedure was developed for H-α-hydroxyphosphinates via Abramov reaction. The present work is a complementary study to those reported till now. This methodology has the advantage that it can be applied to various aliphatic and (hetero)aromatic substrates. The H-α-hydroxyphosphinates were easily purified and obtained in good to excellent yields in shorter times. A 31P NMR spectroscopy study has shown that only 2 equivalents of a silylating agent were required. Keywords Keywordsα-hydroxyphosphinate - synthetic methods - phosphorus - phosphonylation - H-phosphinate Full Text References References 1 Virieux D. Volle JN. Bakalara N. Pirat JL. Top. Curr. Chem. 2015; 360: 39 2 Collinsová M. Jirácek J. Curr. Med. Chem. 2000; 7: 629 3 Grams F. Dive V. Yiotakis A. Yiallouros I. Vassiliou S. Zwilling R. Bode W. Stocker W. Nat. Struct. Biol. 1996; 3: 671 4a Abdel-Meguid SS. Zhao B. Murthy KH. M. Winborne E. Choi J.-K. DesJarlais RL. Minnich MD. Culp JS. Debouck C. Tomashek TA. Jr. Meek TD. Dreyer GB. Biochemistry 1993; 32: 7972 4b Dreyer GB. Metcalf BW. Tomaszek TA. Jr. Carr TJ. Chandler AC. I. Hyland L. Fakhoury SA. Magaard VW. 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