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Synthesis 2019; 51(03): 769-779
DOI: 10.1055/s-0037-1610296
DOI: 10.1055/s-0037-1610296
paper
Palladium-Catalyzed Direct Acylation: One-Pot Relay Synthesis of Anthraquinones
We are grateful to the Department of Science and Technology-Science and Engineering Research Board (DST-SERB) [NO.: SB/S1/OC-39/2014], New Delhi, for the financial support. S.B. thanks MHRD for the award of a research fellowship.Further Information
Publication History
Received: 28 August 2018
Accepted after revision: 31 August 2018
Publication Date:
10 October 2018 (online)
Abstract
A bis-acylation strategy to access functionalized anthraquinones via one-pot relay process, is presented. The first acylation was feasible under [Pd]-catalyzed intermolecular direct acylation reaction, while, the second acylation was accomplished by using intramolecular Friedel–Crafts acylation. Notably, benchtop aldehydes have been utilized as non-toxic acylation agents in the key [Pd]-catalyzed acylation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610296.
- Supporting Information
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