Dedicated to Professor Pavel Kočovský on the occasion of his 68th birthday.
Abstract
This review summarizes the synthetic approaches towards 1,2-substitution pattern on the adamantane framework. Selected are the works containing the directed C–H functionalization step.
1 Introduction
2 Access to 1,2-Disubstituted Derivatives via C–H Insertion Reactions of Electrophilic Organic Species
3 Access to 1,2-Disubstituted Derivatives through Hydrogen Radical Abstraction Reactions
4 Access to 1,2-Disubstituted Derivatives Exploiting Metal-Catalyzed (Promoted) C–H Activations
5 Access to 1,2-Disubstituted Derivatives via Hydride Shift
6 Conclusion
7 Acronyms
Key words
adamantane - diamondoid - C–H functionalization - C–H activation - insertion reactions - hydrogen abstraction reactions - hydride shift