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Synthesis 2019; 51(03): 629-642
DOI: 10.1055/s-0037-1610321
DOI: 10.1055/s-0037-1610321
short review
Directed C–H Functionalization of the Adamantane Framework
This work was supported by the DFG (HR 97/1-1).Weitere Informationen
Publikationsverlauf
Received: 13. September 2018
Accepted after revision: 17. Oktober 2018
Publikationsdatum:
21. November 2018 (online)
Dedicated to Professor Pavel Kočovský on the occasion of his 68th birthday.
Abstract
This review summarizes the synthetic approaches towards 1,2-substitution pattern on the adamantane framework. Selected are the works containing the directed C–H functionalization step.
1 Introduction
2 Access to 1,2-Disubstituted Derivatives via C–H Insertion Reactions of Electrophilic Organic Species
3 Access to 1,2-Disubstituted Derivatives through Hydrogen Radical Abstraction Reactions
4 Access to 1,2-Disubstituted Derivatives Exploiting Metal-Catalyzed (Promoted) C–H Activations
5 Access to 1,2-Disubstituted Derivatives via Hydride Shift
6 Conclusion
7 Acronyms
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